根据《明史》的记载，杨士奇是明代永乐至正统年间的重要政治人物之一，在仁宗、宣宗和英宗三位皇帝的朝代中都担任了重要职务。他的主要事迹如下：

1. 永乐年间：初任翰林编修，后因才学出众被晋升为侍讲，并参与编撰《太祖实录》等重要文献。在仁宗监国期间多次进言，得到重视。

2. 仁宗朝：升任少保、兵部尚书等职，成为內阁重臣之一。他坚持原则，敢于直言，如反对将官员用于牧马的建议，并成功劝说仁宗免除元旦使用音乐的命令。

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