尚質（；1629年10月1日 - 1668年）是琉球國第二尚氏王朝的第10代國王。1648年至1668年在位。童名思德金，是第8代國王尚豐的第四子，也是第9代國王尚賢的弟弟。

1637年，尚質接受佐敷間切的封地，稱佐敷王子；1645年改封中城間切之地。因護得久御殿尚亨（具志川王子朝盈）無嗣，尚質曾被過繼給尚亨當嗣子。1648年，兄尚賢王逝世。尚質被尚亨奉還王室，並繼承了王位。

1650年，尚質王令按司向象賢（羽地王子朝秀）開始編纂《中山世鑑》。同年，清朝遣梁庭漢出使琉球詔諭，但未能到達琉球。1651年，清朝使者謝必振攜琉球使者周國盛至琉球，詔諭尚質歸附。謝必振的船隻於翌年才到達琉球。此時反清復明勢力逐漸衰落，使得尚質開始考慮同清朝正式建立關係。尚質王下令久米村的人不准穿中華衣冠，全部改穿琉球衣冠，並從琉球國俗。

1653年（順治十年），尚質遣王舅馬宗毅、正議大夫蔡祚隆赴京師朝貢，慶祝順治帝登基，並繳納明朝頒發的印綬。翌年順治帝以兵科副禮官張學禮為冊封正使、行人司行人王垓為冊封副使，前往福建造船，準備前去冊封。但鄭成功勢力擁有制海權，故而無法出航。二位冊封使也受到了清廷的處罰。此後琉球以「海氣未靖」為由，不再向清廷朝貢。

1656年，尚質令平啓祥（當間親雲上重陳）利用薩摩藩的廢錢「加治木錢」，鑄造了「鳩目錢」（俗稱「當間錢」），取代京錢（中國錢幣），作為琉球的通用貨幣。不過由於鳩目錢質量極差容易磨損，使得鑄造費用龐大；後來尚質於1662年下令鳩目錢與京錢同為通用貨幣。

1660年，首里城因火災而被焚毀，尚質王遷居於大美御殿。

1662年（康熙元年），鄭成功逝世，清朝逐漸擁有制海權。此時琉球與清朝的關係開始出現轉機。康熙帝令兵科副禮官張學禮、王垓戴罪，再度啟用為正副冊封使，前往琉球，冊封尚質為王。由於首里城尚未修復，這次冊封大典在大美御殿舉行。

為了向清廷謝恩，尚質遣王舅向國用（北谷親方朝暢）、紫金大夫金正春出使清朝；翌年，又派王舅英常春（惠祖親方重孝）、正議大夫林有才慶賀康熙帝的登基。行至梅花津（在今福建長樂市梅花鎮沿海一帶），遭到假扮中國海盜的琉球人的襲擊。英常春等人畏懼而逃；只有蔣思忠（喜屋武築登之元持）奮力抵抗，被殺。金壺等貢品被劫。向國用、英常春歸國後，薩摩藩將犯罪者處決；又以向國用、英常春失職為由，將他們罷官處死。這就是北谷惠祖事件。

在這次事件之後，向象賢（羽地王子朝秀）在薩摩藩的扶持下成為攝政，並對琉球國進行了一系列改革。

1668年，尚質逝世，其子尚貞繼位。

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was a king of the Ryukyu Kingdom who held the throne from 1648 until his death in 1668.

The fourth son of King Shō Hō, he was named Prince of Sashiki in 1637, at the age of eight, and was granted Sashiki magiri as his domain. In 1645, his domain was changed to that of Nakagusuku magiri, and his title to Prince of Nakagusuku.

Shō Shitsu succeeded his brother Shō Ken as king in 1648. His reign coincided with a period of rebellion and instability in China, as factions loyal to the Ming Dynasty, which fell in 1644, continued to fight against the new Qing Dynasty order. On at least one occasion, Ryukyuan tribute ships were attacked by pirates or rebels, who killed at least one of the Ryukyuan sailors and stole various objects; the authorities of Satsuma Domain declared the head envoy and his deputy to be at fault and had them executed. Another incident involved an attack on an Okinawan mission on the road to Beijing; the Ryukyuans defeated their attackers, and Hirata Tentsu came to be known as a national hero.

Though there was initially some uncertainty, particularly within Japan, as to whether the kingdom should support the new dynasty, or the Ming rebels, the Tokugawa shogunate left the decision up to Satsuma. The king's eldest son, Shō Tei, who would later succeed him as king, journeyed to Beijing and submitted the formal royal seal given the kingdom by the Ming rulers, to the Qing Court, which in turn granted the prince a new royal seal for the kingdom and declared its official recognition of Shō Shitsu as king.

A number of major reforms were effected in the final years of Shō Shitsu's reign, primarily at the guidance or suggestion of Shō Shōken, who was appointed sessei, a position which has been compared to prime minister, in 1666. Shō Shōken also compiled the Chūzan Seikan ("Mirror of Chūzan"), the first history of the kingdom, at the king's orders.

Upon his death in 1668, he was entombed in the royal mausoleum Tamaudun, and was succeeded by his eldest son, Shō Tei.